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AssigneeBiogen Idec MA Inc.
InventorsDaniel H.S. Lee, Dingyi Wen, R. Blake Pepinsky, Jane K. Relton, Xinzhong Wang, Alexey Lugovskoy, Werner Meier, Ellen A. Garber, Laura Silvian, Paul H. Weinreb
Estimating the term…
Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
1-127. (canceled)
A NogoR polypeptide variant comprising:
A method of treating a central nervous system (CNS) disease, disorder, or injury in a mammal, comprising administering to a mammal in need of treatment an effective amount of an agent selected from the group consisting of the polypeptide comprising:
A method of treating disease by administering to a subject in need of treatment a composition of a NogoR polypeptide variant comprising:
An isolated polynucleotide comprising a nucleotide sequence that encodes a polypeptide comprising:
An isolated polynucleotide whose sequence matches or is complementary to a portion of a sequence encoding NgR1, which isolated polynucleotide is selected from the group consisting of:
Dependencies are inferred from the claim text.