Method of treating or ameliorating metabolic disorders using clec-2
AssigneeAmgen Inc.
InventorsXinle Wu, Yang Li
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Abstract
Methods of treating metabolic diseases and disorders using a Clec-2 extracellular domain are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, elevated glucose levels, elevated insulin levels and elevated triglyceride levels.
Claims18
A method of treating a metabolic condition in a subject, comprising administering to the subject in need thereof a therapeutically effective amount of a Clec-2 inhibitor, wherein the Clec-2 inhibitor comprises the extracellular domain of the Clec-2 receptor or a fragment thereof.
The method of 13 wherein in the Clec-2 inhibitor comprises a polypeptide comprising an amino acid sequence of SEQ ID 1, 3, 5 or 12.
The method of claim 18, wherein the Clec-2 inhibitor is administered in the form of a pharmaceutical composition comprising a therapeutically effective amount of the Clec-2 inhibitor in admixture with a pharmaceutically-acceptable carrier.
Dependencies are inferred from the claim text.