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US 2014/0227240 A1Published application
Regeneration of Spinal Discs
AssigneeLaser Spine Institute, LLC
InventorMark Flood
Life of this patent
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Abstract
Compositions and processes for the effective and efficient regeneration of spinal discs are provided. These compositions contain stem cells, donor cells, and platelet plasma compositions. By using these compositions, there is an increased likelihood of acceptance and proper cell differentiation.
Claims29
A composition for regenerating a disc, said composition comprising:
- (a) stem cells from a subject;
- (b) donor disc cells, wherein the donor disc cells are derived from a non-degenerative level of a spine of the subject;
- and
- (c) a platelet plasma composition.
1 more element
A process for creating a composition for disc regeneration, said process comprising:
- (a) morselizing donor disc material, wherein the donor disc material comprises healthy cells obtained from a non-degenerative level of a spine;
- (b) extruding the donor disc material to form an extruded material that comprises chondrocytes and an extracellular matrix;
- and
- (c) mixing the chondrocytes, the extra cellular matrix, a bone marrow aspirate, wherein the bone marrow aspirate comprises stem cells and a platelet plasma composition, wherein the platelet plasma composition comprises growth factors to form a composition for disc regeneration.
1 more element
A process for regenerating a disc, said process comprising:
- (a) harvesting bone marrow from a person;
- (b) generating bone marrow aspirate and a platelet plasma composition from the bone marrow, wherein the bone marrow aspirate comprises mesenchymal stem cells, plasma, platelets and red blood cells;
- (c) harvesting disc chondrocytes and an extra cellular matrix from non-degenerative disc tissue of the person;
- and
- (d) combining the bone marrow aspirate and the disc chondrocytes to form a composition under conditions that permit the mesenchymal stem cells to begin differentiation.
2 more elements
Dependencies are inferred from the claim text.