Methods and Compositions for Delivery of Exogenous Factors to Nervous System Sites
AssigneesAlbany Medical College, Regenerative Research Foundation
InventorsSally Temple Stern, Natalia Lowry, Jeffrey Stern, Susan K. Goderie
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Abstract
The present invention relates to treatment methods and methods for sustained delivery of one or more exogenous factors to desired nervous system sites. In certain embodiments, the invention relates to the use of biodegradable microspheres to deliver exogenous factors, such as the morphogenic factor, sonic hedgehog (Shh), to the site of spinal cord injury. In certain embodiments, the Shh-releasing microspheres are administered together with stem cells, which may be spinal cord neural stem cells. In certain embodiments, the invention relates to regrowth of neural cells in both the central and peripheral nervous systems.
Claims32
A method for treating a nervous system injury in a mammal comprising administering to a mammal in need of such treatment an effective amount for treating the nervous system injury of a pharmaceutical formulation comprising at least one exogenous factor, said pharmaceutical formulation providing sustained delivery of the at least one exogenous factor for at least about 7 days.
(canceled)
A method for increasing neural cell growth or regenerating neural cells in a mammal which comprises administering to a mammal in need of such treatment an effective amount for increasing neural cell growth or regenerating neuronal cells of a sustained release pharmaceutical formulation comprising at least one exogenous factor, said pharmaceutical formulation continuously delivering the at least one exogenous factor for at least about 7 days.
(canceled)
A pharmaceutical composition which comprises an effective amount for increasing neuronal cell growth or regenerating neuronal cells of at least one sustained delivery composition comprising at least one exogenous factor selected from the group consisting of Nerve Growth Factor (NGF), Glial Cell Line-Derived Growth Factor (GDNF), Neurotrophin (NT) 3, NT 4/5, NT 6, Ciliary Neurotrophic Factor (CNTF), Leukemia Inhibitory Factor (LIF), Interleukin 6 (IL6), Interleukin 11 (IL11), Cardiotrophin 1, a growth factor hormone, hyaluronidase, chondroitinase ABC(CABC), basic fibroblast growth factor (bFGF), insulin-related growth factor (IGF-1), brain derived neurotrophic factor (BDNF), epidermal growth factor (EGF), and sonic hedgehog (Shh), wherein the composition provides sustained delivery of at least one exogenous factor for at least 7 days, and a pharmaceutically acceptable excipient.
(canceled)
Dependencies are inferred from the claim text.