Pharmaceutical Compositions of Conjugates Formed From Polymer Derivatives Having Particular Atom Arrangements

A pharmaceutical preparation comprising

• (i) a conjugate of the following structure,
• wherein:
• POLY1 is a poly(alkylene glycol);
• POLY2 is a poly(alkylene glycol);
• (a) is 0, 1, 2 or 3;
• (b) is 0, 1, 2 or 3;
• (e) is 0, 1, 2 or 3;
• (f′) is 0, 1, 2 or 3;
• (g′) is 0, 1, 2 or 3;
• (h) is 0, 1, 2 or 3;
• (j) is 0 to 20;
• each R1 is independently H or an organic radical selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl and substituted aryl;
• X1, when present, is a first spacer moiety;
• X2, when present, is a second spacer moiety;
• X5, when present, is a fifth spacer moiety;
• X6, when present, is a sixth spacer moiety;
• X7, when present, is a seventh spacer moiety;
• X8, when present, is an eighth spacer moiety;
• R5 is a branching moiety selected from the group consisting of
• wherein (p) is 1-10 and (q) is 1-10;
• and
• Active Agent is a residue of a pharmacologically active agent;
• and
• (ii) a pharmaceutically acceptable excipient.