L-glutamic acid and l-glutamine derivative (iii), use thereof and method for obtaining them

Compound of the general Formula I

• wherein
• A is
• a) Hydroxyl,
• b) branched or unbranched C1-C5 alkoxy,
• c) branched or unbranched Hydroxy C1-C5 Alkoxy,
• d) branched or unbranched O—C1-C5 Alkyl-(O—C1-C4 alkyl)n-O—C1-C4 alkyl,
• e) N(C1-C5 Alkyl)2,
• f) NH2,
• g) N(H)-L,
• h) O-L or
• i) O—Z,
• and G is
• a) Hydroxyl,
• b) O—Z
• b) branched or unbranched O—C1-C5 Alkyl,
• c) branched or unbranched O—C2-C5 Alkenyl,
• d) branched or unbranched O—C1-C5 Alkyl-(O—C1-C4 alkyl)n-O—C1-C4 alkyl or
• e) branched or unbranched O—C2-C5 Alkinyl,
• and R1 and/or R2, independently separate are
• a) Hydrogen,
• b) branched or unbranched 19F—C1-C10 Alkoxy,
• c) branched or unbranched 19F—C1-C10 Alkyl,
• d) branched or unbranched 19F—C2-C10 Alkenyl,
• e) branched or unbranched 19F—C2-C10 Alkinyl,
• f) substituted or unsubstituted 19F—C6-C10 mono- or bicyclic Aryl,
• g) substituted or unsubstituted 19F-alkyl-C6-C10 mono- or bicyclic Aryl
• h) substituted or unsubstituted 19F—C5-C10 mono- or bicyclic Heteroaryl,
• i) substituted or unsubstituted 19F-alkyl-C5-C10 mono- or bicyclic Heteroaryl
• j) substituted or unsubstituted 19F—C3-C6 Cyclo-Alkyl,
• k) substituted or unsubstituted 19F-alkyl-C3-C6 Cyclo-Alkyl
• l) Hydroxyl,
• m) branched or unbranched C1-C5 Alkyl or
• n) branched or unbranched C1-C5 Alkoxy
• wherein alkyl is optionally interrupted or is replaced by O, S or N,
• with the proviso that one of the substituent R1 or R2 comprises 19F atom and the other substituent comprises no 19F atom,
• and L is
• a) branched or unbranched C1-C5 Alkyl,
• b) branched or unbranched C2-C5 Alkenyl,
• c) branched or unbranched C1-C5 Alkyl-(O—C1-C4 alkyl)n-O—C1-C4 alkyl or
• d) branched or unbranched C2-C5 Alkinyl,
• and Z is a metal ion equivalent,
• with the meaning of n=0, 1, 2 or 3, and
• wherein mixtures of all possible diastereomers and/or enantiomers as well as enantiomerically pure compounds and pharmaceutical salts thereof are comprised.