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AssigneesBoard of Regents, The University of Texas System, The Methodist Hospital System
InventorsChin-Hsuan Tung, Wael Refat Adb-Elgaliel, Craig D. Logsdon, Zobeida Cruz-Monserrate
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Provided herein are compositions and kits comprising a therapeutic agent linked to a cleavable substrate, wherein the cleavable substrate is capable of being cleaved by cathepsin E. Also provided are methods of treating one or more symptoms of a disease or disorder characterized by expression of cathepsin E in a subject and methods of eliminating a cancer cell characterized by expression of cathepsin E using the provided compositions and kits. Further provided herein are methods of detecting the presence of a cancer cell or detecting a cathepsin E expressing cell using a photosensitizer linked to a cleavable substrate, wherein the cleavable substrate is capable of being cleaved by cathepsin E.
A composition comprising a photosensitizer linked to a cleavable substrate, wherein the cleavable substrate is capable of being cleaved by cathepsin E.
A composition comprising a chemotherapeutic agent linked to a cleavable substrate, wherein the cleavable substrate is capable of being cleaved by cathepsin E.
A method of treating one or more symptoms of a disease or disorder characterized by expression of cathepsin E in a subject comprising the steps of:
A method of treating one or more symptoms of a disease or disorder characterized by expression of cathepsin E in a subject comprising the steps of:
A method of detecting the presence of a cancer cell comprising the steps of:
A method of detecting a cathepsin E expressing cell comprising the steps of:
Dependencies are inferred from the claim text.