Cathepsin-binding compounds bound to a carrier and their diagnostic use
AssigneeJ. Stefan Institute
InventorsOlga Vasiljeva, Georgy Mikhaylov, Boris Turk, Norbert Schaschke
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Abstract
The invention relates to Cathepsin-binding compounds bound to a carrier comprising a diagnostic moiety, for use in the diagnosis of inflammatory diseases, and/or for use in the diagnosis of neoplastic diseases, wherein the Cathepsin-binding compound binds to inflammatory cells of the tumour stroma. The invention also relates to Cathepsin B-targeting compounds and Cathepsin B-binding and liposome-binding compounds.
Claims22
1-24. (canceled)
A Cathepsin-binding compound bound to a carrier comprising a diagnostic moiety,
- (i) for use in the diagnosis of inflammatory diseases, and/or
- (ii) for use in the diagnosis of neoplastic diseases, wherein the Cathepsin-binding compound binds to inflammatory cells of the tumour stroma.
A Cathepsin-binding and liposome-binding compound, in particular a Cathepsin B-binding and liposome-binding compound or Cathepsin S-binding and liposome-binding compound, more preferably a Cathepsin B-binding and liposome-binding compound, comprising:
- (i) a Cathepsin-binding moiety, in particular a Cathepsin B-binding moiety or Cathepsin S-binding moiety, more preferably a Cathepsin B-binding compound,
- (ii) optionally a linker, and
- (iii) a liposome-binding moiety.
A Cathepsin targeting compound, in particular a Cathepsin B-targeting compound or Cathepsin S-targeting compound, comprising a Cathepsin binding and liposome-binding compound of claim 9, bound to a liposome.
Dependencies are inferred from the claim text.