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AssigneesThe Regents of the University of California, Convoy Therapeutics
InventorsJohn A. Muraski, Samir Mitragotri, Ming Chen
Estimating the term…
Compositions that facilitate the delivery of an active agent or an active agent carrier wherein the compositions are capable of penetrating the stratum corneum (SC) and/or the cellular membranes of viable cells are provided. In some embodiments, the compositions include a peptide, an active agent, and a carrier that includes the active agent, wherein the peptide has an amino acid sequence set forth in any of SEQ ID NOs: 1-18; the peptide is associated with and/or conjugated to the active agent, the carrier, or both; the carrier is selected from the group consisting of a micelle, a liposome, an ethosome, and combinations thereof; and the composition is capable of penetrating a stratum corneum (SC) layer when contacted therewith or penetrating a cell when contacted therewith, and optionally wherein the composition further includes one or more free peptides having an amino acid sequence set forth in any of SEQ ID NOs: 1-18. Also provided are methods for delivering active agents to subjects, methods for treating subjects having dermatological diseases, and methods for attenuating expression of mRNAs of subjects in need thereof and/or for treating diseases and/or disorders thereby.
A composition comprising a peptide, an active agent, and a carrier comprising the active agent, wherein:
A composition comprising a peptide, an active agent, and a carrier comprising the active agent, wherein:
A method for delivering an active agent to a subject, comprising administering to the subject a composition comprising a peptide comprising an amino acid sequence set forth in any of SEQ ID NOs:
21-72. (canceled)
Dependencies are inferred from the claim text.