Novel cochleate formulations
AssigneeRutgers, The State University of New Jersey
InventorsLeila Zarif, Tuo Jin, Ignacio Segarra, Raphael J. Mannino
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Abstract
A process for producing a small-sized, lipid-based cochleates. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.
Claims1
A cochleate composition comprising a population of cochleates, wherein the cochleates comprise:
- a negatively charged first lipid;
- a divalent cation or higher valency cation and
- an additional biologically relevant molecule,
- wherein the mean particle size of the cochleates is less than one micron.
Dependencies are inferred from the claim text.