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US 2014/0213736 A1Published application
Process for the preparation of sevelamer
AssigneeLaboratorio Chimico Internazionale S.p.A.
InventorsFlavio VILLANI, Bruno DE ANGELIS, Antonio NARDI, Maria PATERNOSTER
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Abstract
The present invention relates to a process for the preparation of sevelamer, in particular sevelamer hydrochloride and sevelamer carbonate/bicarbonate, by means of a process that allows sevelamer to be obtained with good yields and using conventional reactors, without requiring to use specific and expensive equipment.
Claims11
1-11. (canceled)
A process for the preparation of sevelamer characterized in that it comprises the following steps:
- (a) partially salifying a polyallylamine aqueous solution having a concentration between 10% and 14.5% (w/w);
- (b) adding epichlorohydrin;
- (c) maintaining the reaction mixture under stirring;
- (d) isolating the sevelamer thus obtained;
- characterized in that the steps from (a) to (c) are carried out in the absence of any organic solvents,
- characterized in that the polyallylamine is salified up to a degree of salification of 25-40%, and
- wherein the polyallylamine is salified by an acid.
4 more elements
Dependencies are inferred from the claim text.