Prostaglandin compositions and methods for the treatment of vasospasm

A method of improving vasospasm comprising:

• applying directly to a surface of a tissue of a subject needing improvement of vasospasm a composition comprising:
• one or more of prostaglandin E1, a pharmaceutically acceptable salt of prostaglandin E 1, and a C1 to C4 alkyl ester of prostaglandin E1 or a pharmaceutically acceptable salt thereof, wherein the dose per application is about 0.08 mg to about 0.64 mg of prostaglandin E1;
• a penetration enhancer selected from the group consisting of an alkyl-(N-substituted amino) ester elected from the group consisting of an alkyl-(N-substituted amino) alkanoate, an alkyl-2-(N,N-disubstituted amino) alkanoate, an (N-substituted amino) alkanol alkanoate, an (N,N-disubstituted amino) alkanol alkanoate, a pharmaceutically acceptable salt thereof, and a mixture thereof;
• a shear-thinning polymer thickener selected from the group consisting of a shearthinning polysaccharide gum and a shear-thinning polyacrylic acid polymer;
• a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof;
• water and
• a buffer system that provides a buffered pH.

A method of improving vasospasm in an ear of a subject comprising:

• applying directly to a surface of the ear of the subject needing improvement of vasospasm a composition comprising:
• one or more of prostaglandin E1, a pharmaceutically acceptable salt of prostaglandin E1, and a C1 to C4 alkyl ester of prostaglandin E1 or a pharmaceutically acceptable salt thereof, wherein the dose per application is about 0.08 mg to about 0.64 mg prostaglandin E1;
• a penetration enhancer selected from the group consisting of an alkyl-(N-substituted amino) ester elected from the group consisting of an alkyl-(N-substituted amino) alkanoate, an alkyl-2-(N,N-disubstituted amino) alkanoate, an (N-substituted amino) alkanol alkanoate, an (N,N-disubstituted amino) alkanol alkanoate, a pharmaceutically acceptable salt thereof, and a mixture thereof;
• a shear-thinning polymer thickener selected from the group consisting of a shearthinning polysaccharide gum and a shear-thinning polyacrylic acid polymer;
• a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof;
• water and
• a buffer system that provides a buffered pH.