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US 2014/0213653 A1Published application
Directly compressible proprionic acid derivative particles
AssigneeMcNeil-PPC, Inc.
InventorsSaumitra Bagchi, Murali K. Vuppala
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Abstract
A compressed tablet containing directly compressible propionic acid derivative particles is disclosed. A method of manufacturing a compressed tablet containing the directly compressible propionic acid derivative particles; and methods of treatment using the compressed tablet are also disclosed.
Claims9
A method of manufacturing a compressed tablet, comprising:
- melting a propionic acid derivative and a wax while mixing;
- dispersing the molten propionic acid derivative/wax mixture in hot water;
- transferring the hot propionic acid derivative/wax/water dispersion into another container containing cold water, wherein the dispersed droplets of propionic acid derivative/wax congeal and form fine/spherical particles;
- filtering and drying the fine/spherical particles;
- mixing the filtered and dried fine/spherical particles with dosage form excipients;
- and
- compressing the mixture into a dosage form.
4 more elements
Dependencies are inferred from the claim text.