Methods of increasing epa blood levels

A method of reducing a ratio of arachidonic acid to EPA (AA/EPA) in plasma or RBCs of a subject having baseline fasting triglycerides of at least about 500 mg/dl, the method comprising administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of EPA per day, wherein upon administering the composition to the subject daily for a period of 12 weeks, the subject exhibits a decrease in AA/EPA in plasma and/or RBCs of at least 50% compared to a control subject who is not administered EPA, wherein the control subject also has baseline fasting triglycerides of at least about 500 mg/dl.

A method of reducing a ratio of omega-3 fatty acids to omega-6 fatty acids (n-3/n-6) in plasma or RBCs of a subject having baseline fasting triglycerides of about 200 mg/dl to about 500 mg/dl and on stable statin therapy, the method comprising administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of EPA per day, wherein upon administering the composition to the subject daily for a period of 12 weeks, the subject exhibits a decrease in n-3/n-6 in plasma and/or RBCs of at least 50% compared to a control subject who is not administered EPA, wherein the control subject also has baseline fasting triglycerides of at least about 500 mg/dl.

A method of increasing a ratio of omega-3 fatty acids to total fatty acids in plasma or RBCs of a subject having baseline fasting triglycerides of at least about 500 mg/dl, the method comprising administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of EPA per day, wherein upon administering the composition to the subject daily for a period of 12 weeks, the subject exhibits an increase in the ratio of omega-3 fatty acids to total fatty acids in plasma and/or RBCs of at least 20% compared to a control subject who is not administered EPA, wherein the control subject also has baseline fasting triglycerides of at least about 500 mg/dl.

A method of decreasing a ratio of omega-6 fatty acids to total fatty acids in plasma or RBCs of a subject having baseline fasting triglycerides of at least about 500 mg/dl, the method comprising administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of EPA per day, wherein upon administering the composition to the subject daily for a period of 12 weeks, the subject exhibits a decrease in the ratio of omega-6 fatty acids to total fatty acids in plasma and/or RBCs of at least 5% compared to a control subject on stable statin therapy without EPA, wherein the control subject also has baseline fasting triglycerides of about 200 mg/dl to about 500 mg/dl.