Compositions and Biomarkers for Heart Disease, Injury and Failure and Methods of Use
AssigneeDuke University
InventorsDawn E. Bowles, Carmelo A. Milano, Valentino Piacentino, Matthew Schechter
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Abstract
The present disclosure provides biomarkers useful for determining the risk of, prognosis of, and/or diagnosis of conditions such as ischemic and/or non-ischemic heart failure in a subject.
Claims5
A method of treating a cardiac disease or disorder and/or improving cardiac function in a subject in need thereof, comprising administering to the subject an effective amount of a substance that modulates the expression of nucleic acid encoding fetuin A in cells of the subject, thereby treating the cardiac disease or disorder and/or reducing fibrosis associated with the cardiac disease or disorder and/or improving cardiac function in the subject.
2-8. (canceled)
A method of treating a cardiac disease or disorder and/or improving cardiac function in a subject in need thereof, comprising administering to the subject an effective amount of a nucleic acid molecule that encodes the amino acid sequence of C6ORF142, wherein the amino acid sequence is modified to lack Ser67 phosphorylation, thereby treating the cardiac disease or disorder and/or improving cardiac function in the subject.
A method of treating a cardiac disease or disorder and/or improving cardiac function in a subject in need thereof, comprising administering to the subject an effective amount of a substance that modulates the amount and/or activity of C6ORF142 and/or inhibits phosphorylation of Ser67 of C6ORF142, thereby treating the cardiac disease or disorder and/or improving cardiac function in the subject.
11-19. (canceled)
Dependencies are inferred from the claim text.