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US 2014/0213623 A1Published application
Compounds for treatment of cancer
AssigneesGTx, Inc., University of Tennessee Research Foundation
InventorsDuane D. Miller, Li Wei, Jianjun Chen, James T. Dalton, Chien-Ming Li, Sunjoo Ahn
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Abstract
The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a method of using thereof in the treatment of various forms of cancer.
Claims30
A compound represented by formula XXII:
- wherein
- A is indolyl;
- wherein said A is optionally substituted by substituted or unsubstituted O-alkyl, O-haloalkyl, F, Cl, Br, I, haloalkyl, CF3, CN, —CH2CN, NH2, hydroxyl, —(CH2)iNHCH3, —(CH2)iNH2, —(CH2)iN(CH3)2, —OC(O)CF3, substituted or unsubstituted —SO2-aryl, substituted or unsubstituted C1-C5 linear or branched alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkylamino, substituted or unsubstituted aminoalkyl, —OCH2Ph, substituted or unsubstituted —NHCO-alkyl, COOH, substituted or unsubstituted —C(O)Ph, substituted or unsubstituted C(O)O-alkyl, C(O)H, —C(O)NH2, NO2 or combination thereof;
- and
- i is an integer between 0-5;
- R1 is hydrogen, linear or branched, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, —CH2Ph, substituted benzyl, haloalkyl, aminoalkyl, —OCH2Ph, substituted or unsubstituted SO2-aryl, substituted or unsubstituted —(C═O)-aryl or OH;
- or an N-oxide thereof, or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.