Pyridone amides as modulators of sodium channels
AssigneeVertex Pharmaceuticals Incorporated
InventorsSara Sabina Hadida-Ruah, Corey Anderson, Vijayalaksmi Arumugam, Iuliana Luci Asgian, Brian Richard Bear, Andreas P. Termin, James Philip Johnson
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Abstract
The invention relates to pyridone amide compounds of formula I and I′ or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
Claims33
A compound of formula I or I′
- or a pharmaceutically acceptable salt thereof,
- wherein, independently for each occurrence:
- G is
- X is a bond or C1-C6 alkyl wherein said C1-C6 alkyl is substituted with 0-6 halogen, wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with —O—;
- RX is absent, H, or C3-C8 cycloaliphatic, wherein up to two non-adjacent CH2 units of said C3-C8 cycloaliphatic may be replaced with —O— and said C3-C8 cycloaliphatic is substituted with 0-3 substituents selected from halogen and C1-C4 alkyl;
- R1 is H, halogen, CN, or C1-C6 alkyl wherein said C1-C6 alkyl is substituted with 0-6 halogen and wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with —O—;
- R2 is H, halogen, CN, or C1-C6 alkyl wherein said C1-C6 alkyl is substituted with 0-6 halogen, wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with —O—;
- R3 is H, halogen, CN, or C1-C6 alkyl wherein said C1-C6 alkyl is substituted with 0-6 halogen, wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with —O—;
- R4 is H, halogen, CN, or C1-C6 alkyl wherein said C1-C6 alkyl is substituted with 0-6 halogen, wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with —O—;
- R5 is H, halogen, CN, or —X—RX;
- R5′ is H, halogen, CN, or —X—RX;
- R6 is H, halogen, CN, or —X—RX;
- R6′ is H, halogen, CN, or —X—RX;
- R7 is H, halogen, CN, or —X—RX;
- R8 is halogen, or C1-C6 alkyl wherein said C1-C6 alkyl is substituted with 0-6 halogen, wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with —O—;
- p is an integer from 0 to 3 inclusive;
- and
- R9 is H, or C1-C6 alkyl wherein up to two non-adjacent CH2 units of said C1-C6 alkyl may be replaced with —O—.
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The compound or pharmaceutically acceptable salt according to claim 13, wherein R3 is t-butyl, CF3 or CF2CF3.
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Dependencies are inferred from the claim text.