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US 2014/0213609 A1Published application
Promoting axon renegeration in the adult cns through control of protein translation
AssigneeChildren's Medical Center Corporation
InventorsZhigang HE, Kevin PARK, Kai LIU, Yang HU
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Abstract
Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.
Claims8
A method for promoting survival of, or axon regeneration in a lesioned mature neuron in situ, comprising contacting the lesioned neuron with a therapeutically effective amount of a PTEN inhibitor, to thereby promote survival of, or axon regeneration in the neuron.
Dependencies are inferred from the claim text.