Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors

A compound of Formula (I):

• or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein:
• L is —(CH(CH3))y—(CH2)x—(CHR4)x, —O—(CH2)x—(CH(CH3))w—, or —O—(CH(CH3))y—(CH2)x—(CH(CH3))w—, wherein x is an integer selected from 1 through 4, and y and w are independently 0 or 1;
• R1 is selected from the group consisting of:
• methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, —CH2C(CH3)3, —CH2CH(CH3)CH2CH3, —(CH2)2CH(CH3)25—CH(CH2CH3)2, —CH(CH3)CH2CH(CH3)2, —(CH2)2C(CH3)3, —(CH2)2OH, —(CH2)2OCH3, —(CH2)2OCH2CH3, —(CH2)2—O—(CH2)2CH3, —(CH2)2OCH(CH3)2, —(CH2)3—O—(CH2)3CH3, —(CH2)3OCH2CH(Et)(CH2)3CH3, —(CH2)2NHCH(CH3)2, —(CH2)3NHCH(CH3)25—(CH2)3N(CH2CH3)2, —CH2CO2H, —(CH2)2CO2H, —(CH2)3CO2H, —CH2CO2Et, —(CH2)2CO2Et, —CH2CONH2, —CH2CONHMe, —CH2CONMe2, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, 4-OMe-phenyl, 4-OH-phenyl, 4-F-phenyl, 4-Br-phenyl, 2-CF3-phenyl, 4-CN-phenyl, 2,4-difluorophenyl, 3-F-5-CF3-phenyl, benzyl, 2-Me-benzyl, 3-Me-benzyl, 4-Me-benzyl, 2-OMe-benzyl, 3-OMe-benzyl, 3-F-benzyl, 4-F-benzyl, 3-Cl-benzyl, 4-Br-benzyl, 2-CO2H-benzyl, 3-CO2H-benzyl, 4-CO2H-benzyl, 3-CO2Me-benzyl, 4-CO2Me-benzyl, 2,4-difluorobenzyl, 2,5-difluorobenzyl, 2,6-difluorobenzyl, 2,4-dichlorobenzyl, 3,4-dichlorobenzyl, 3,5-dichlorobenzyl, phenethyl, 3-Me-phenethyl, 4-Me-phenethyl, 2-OMe-phenethyl, 3-OMe-phenethyl, 4-OMe-phenethyl, 4-OH-phenethyl, 2-F-phenethyl, 3-F-phenethyl, 4-F-phenethyl, 2-Cl-phenethyl, 3-Cl-phenethyl, 4-Cl-phenethyl, 3-CF3-phenethyl, 4-CO2H-phenethyl, 3,4-dimethoxyphenethyl, 2,5-difluorophenethyl, —(CH2)4-Ph, —CH(CH3)-Ph, —CH2CH(CH3)-Ph, —CH(CH3)(CH2)2-Ph, —CH(CH3)-(4-F-Ph), —(CH2)2O-Ph, —(CH2)2O-(4-F-Ph), 4-pyridyl, —CH2-(2-pyridyl), —CH2-(3-pyridyl), —CH2-(4-pyridyl), —(CH2)2-(4-pyridyl),
• R3 is selected from the group consisting of:
• H, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, —CH2C(CH3)3, —CH(CH2CH3)2, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, 4-F-phenyl, 2-Cl-phenyl, 3-Cl-phenyl, 2-CF3-phenyl, 3,4-dichlorophenyl, benzyl, 4-Me-benzyl, phenethyl,
• R4 is selected from the group consisting of:
• methyl, ethyl, i-propyl, and phenyl;
• R5 is selected from the group consisting of:
• phenyl, 2-Me-phenyl, 3-Me-phenyl, 4-Me-phenyl, 3-OMe-phenyl, 4-OMe-phenyl, 3-OH-phenyl, 2-F-phenyl, 3-F-phenyl, 4-F-phenyl, 2-Cl-phenyl, 3-Cl-phenyl, 4-Cl-phenyl, 2-Br-phenyl, 2-CF3-phenyl, 3-CF3-phenyl, 4-CF3-phenyl, 3-CO2Me-phenyl, 4-CO2Me-phenyl, 3,4-dimethylphenyl, 3,4-dimethoxyphenyl, 2-OMe-4-CN-phenyl, 3,4-difluorophenyl, 2,4-dichlorophenyl, 3,4-dichlorophenyl, 2,6-dichlorophenyl, 3-CF3-4-Me-phenyl, 1-naphthyl, 2-naphthyl, 6-OMe-pyrid-2-yl, 5-Me-6-OMe-pyrid-3-yl, and 5-Me-6-F-pyrid-3-yl;
• provided, however, that when R1 is methyl and R3 is hydrogen:
• (1) if L is —CH2—, then R5 is not 4-CH3O—C6H4—;
• (2) if L is —(CH2)2—, then R5 is not PhO— or 3,4-di-C1-C6H3—;
• (3) if L is —(CH2)3—, then R5 is not phenyl or 3,4-di-C1-C6H3—;
• and
• (4) if L is —(CH2)4—, then R5 is not phenyl.