Prmt5 inhibitors and uses thereof

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof,
• wherein
• represents a single or double bond;
• Ring A is an optionally substituted, 5- to 12-membered, monocyclic or bicyclic, heterocyclyl or heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• R1 is hydrogen, Rz, or —C(O)Rz, wherein Rz is optionally substituted C1-6 alkyl;
• Y is O or S;
• R5, R6, R7, and R8 are independently hydrogen, halo, or optionally substituted aliphatic;
• each Rx is independently selected from the group consisting of halo, —CN, optionally substituted aliphatic, —OR′, and —N(R″)2;
• R′ is hydrogen or optionally substituted aliphatic;
• each R″ is independently hydrogen or optionally substituted aliphatic, or two R″ are taken together with their intervening atoms to form a heterocyclic ring;
• and
• n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10, as valency permits.