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US 2014/0213552 A1Published application
Cyclohexylamines
AssigneeEndo Pharmaceuticals Inc.
InventorsScott Kevin Thompson, Roger Astbury Smith, Sandeep Gupta, Tony Priestley, Nicholas James Laping, Ashis K. Saha, Sonali Rudra
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Abstract
The present application provides novel compounds and methods for preparing and using these compounds. These compounds are useful in treating pain, itch, overactive bladder and/or interstitial cystitis in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) and a TRPV1 receptor activator. In one embodiment, the TRPV1 receptor activator is lidocaine.
Claims61
A compound of formula (I):
- wherein:
- R1 is H or C1 to C6 alkyl;
- R2 is C1 to C6 alkyl;
- or two R2 are joined together to form a 5- or 6-membered ring;
- Y is O or CHR3;
- R3 is H or C1 to C6 alkyl;
- A is optionally substituted phenyl, optionally substituted heteroaryl or optionally substituted cycloalkyl, with the proviso that when A is unsubstituted phenyl, R1 and R2 are not methyl and R3 is not H;
- X is chloride, bromide, iodide, trifluoroacetate, sulfate, phosphate, acetate, fumarate, maleate, citrate, pyruvate, succinate, oxalate, sulfonate, bisulfate, malonate, xinafoate, ascorbate, oleate, nicotinate, saccharinate, adipate, formate, glycolate, L-lactate, D-lactate, aspartate, malate, L-tartrate, D-tartrate, stearate, 2-furoate, 3-furoate, napadisylate, edisylate, isethionate, D-mandelate, L-mandelate, propionate, tartrate, phthalate, hydrochlorate, hydrobromate, nitrate, methanesulfonate, napthalenesulfonate, benzenesulfonate, toluenesulfonate, camphorsulfonate or trifluoromethanesulfonate.
5 more elements
Dependencies are inferred from the claim text.