Intestinal hyperpermeability and prevention of systemic disease
AssigneeThomas Jefferson University
InventorsScott A. Waldman, Adam E. Snook, Peng Li, Jieru Egeria Lin
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Abstract
Compositions for and methods of preventing or reducing the severity intestinal hyperpermeabilization in an individual are disclosed. Compositions for and methods of preventing or reducing the severity of a disease or condition caused or exacerbated by intestinal hyperpermeabilization in an individual identified as being at risk of a disease or condition caused or exacerbated by intestinal hyperpermeabilization are also disclosed. Compositions for and methods of treating an individual who has been identified as having a disease or condition caused or exacerbated by intestinal hyperpermeabilization are additionally disclosed.
Claims22
A method of preventing or reducing the severity of a disease or condition which is caused or exacerbated by intestinal hyperpermeabilization in an individual identified as being at risk of a disease or condition which is caused or exacerbated by intestinal hyperpermeabilization comprising the step of:
- administering to the individual an amount of one or more compounds that elevates intracellular cGMP levels in intestinal cells sufficient prevent or reduce intestinal hyperpermeabilization by an amount sufficient to prevent or reduce the severity of the disease or condition which is caused exacerbated by intestinal hyperpermeabilization.
A method of treating an individual who has been identified as having a disease or condition which is caused or exacerbated by intestinal hyperpermeabilization comprising the step of:
- administering to the individual an amount of one or more compounds that elevates intracellular cGMP levels in intestinal cells sufficient prevent or reduce intestinal hyperpermeabilization by an amount sufficient to prevent or reduce the severity of the disease or condition which is caused or exacerbated by intestinal hyperpermeabilization.
7-17. (canceled)
(canceled)
Dependencies are inferred from the claim text.