Use of pleitrophin for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome
AssigneeEvotec International GmbH
InventorsDaria ONICHTCHOUK, Ulrike BURK
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Abstract
The present invention discloses the protein pleitrophin secreted by the developing pancreas, and polynucleotides, which identify and encode this protein. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of pancreatic diseases (e.g. diabetes), obesity, and/or metabolic syndrome.
Claims14
-39. (canceled)
A method for lowering blood glucose level in a subject in need thereof, comprising administering to said subject a medicament comprising an acceptable carrier and a human pleiotrophin polypeptide or a functional fragment thereof.
A method for increasing insulin production by pancreatic β cells or generating functional pancreatic cells that express glucagon in a subject, comprising administering to said subject a medicament comprising an acceptable carrier and a human pleiotrophin polypeptide or a functional fragment thereof.
A method for regulation of body weight in a subject in need thereof, comprising administering to said subject a medicament comprising an acceptable carrier and a human pleiotrophin polypeptide or a functional fragment thereof.
A method according to claim 52, comprising regulating body weight in a subject suffering from obesity.
Dependencies are inferred from the claim text.