Peptide compositions and methods for treating lung injury, asthma, anaphylaxis, angioedema, systemic vascular permeability syndromes, and nasal congestion
AssigneeThe Board of Trustees of the University of Illinois
InventorsYulia A. Komarova, Uzma Saqib, Stephen M. Vogel, Asrar B. Malik
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Abstract
Provided herein are peptide inhibitors of the interaction between End Binding Protein 3 (EB3) and Inositol 1,4,5-Trisphosphate Receptor Type 3 (IP3R3). Also provided are methods and materials for treating lung injury, including acute lung injury, which may include hyperpermeability of lung vessels, vascular leakage, the development of edema, asthma, anaphylaxis, angioedema, systemic vascular permeability syndromes, and nasal congestion.
Claims28
An isolated peptide consisting of an amino acid sequence selected from the group consisting of KFARLWTEIPTAIT (SEQ ID NO:
- 1), FTEIPTI (SEQ ID NO:
- 3), a fragment thereof, and a variant thereof.
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An isolated peptide comprising a sequence selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO:
- 3, a fragment thereof, and a variant thereof.
Dependencies are inferred from the claim text.