Cyclodextrin-Based Polymers for Therapeutic Delivery

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A CDP-therapeutic peptide conjugate, wherein the CDP-therapeutic peptide conjugate has the following formula:

• wherein each L is independently a linker or absent and each D is independently a therapeutic peptide, a prodrug thereof, or absent, and wherein the group
• has a Mw of 5 kDa or less and n is at least 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20, provided that the polymer comprises at least one therapeutic peptide.

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A method of making a CDP-therapeutic peptide conjugate comprising:

• providing a therapeutic peptide and a CDP;
• and
• subjecting the therapeutic peptide and CDP to conditions that affect the covalent attachment of the therapeutic peptide to the CDP.

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