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US 2014/0213502 A1Published application
Chemical modification of apolipoprotein mimetic peptides for the production of therapeutic agents
AssigneesUnited States Department of Health and Human Services, KineMed, Inc.
InventorsAlan T. Remaley, Marcelo Amar, Denis Sviridov, Imoh Z. Ikpot, David Osei-Hwedieh, Scott Turner
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Abstract
Hydrocarbon stapling of apolipoprotein mimetic peptides increases the helicity of the peptides, enhances their ability to promote cholesterol efflux by multiple mechanisms and makes them resistant to proteolysis. Hydrocarbon stapled amphipathic helical peptides are useful in the treatment of cardiovascular diseases and other disorders.
Claims9
A stapled apolipoprotein mimetic peptide, wherein the peptide comprises S1A10 or S2A10.
A composition comprising a hydrocarbon stapled apolipoprotein mimetic peptide.
Dependencies are inferred from the claim text.