Back to results
US 2014/0213474 A1Published application
Glucocorticoid receptor alleles and uses thereof
AssigneeShriners Hospitals for Children
InventorsKiho Cho, David G. Greenhalgh
Life of this patent
Estimating the term…
Abstract
Provided here in are, inter alia, methods of determining whether a patient is resistant or sensitive to glucocorticoid therapy.
Claims18
A method of determining whether a subject is resistant to glucocorticoid treatment, the method comprising:
- obtaining a biological sample from the subject;
- and
- analyzing the sample for the presence a glucocorticoid receptor (GR) nucleic acid comprising one or more mutations and encoding a GR polypeptide with decreased transactivation potential as compared to a reference GR polypeptide comprising SEQ ID NO:
- 2, and wherein the presence of the GR nucleic acid indicates that the subject is resistant to glucocorticoid treatment.
1 more element
A method of determining whether a subject is hypersensitive to glucocorticoid treatment, the method comprising:
- obtaining a biological sample from the subject;
- and
- analyzing the sample for the presence a glucocorticoid receptor (GR) nucleic acid comprising one or more mutations and encoding a GR polypeptide with increased transactivation potential as compared to a reference GR polypeptide comprising SEQ ID NO:
- 2, and wherein the presence of the GR nucleic acid indicates that the subject is hypersensitive to glucocorticoid treatment.
1 more element
A kit, the kit comprising:
- (a) means for detecting whether a subject has a GR nucleic acid sequence comprising one or more mutations;
- and
- (b) instructional material for using the kit.
Dependencies are inferred from the claim text.