Phenytoin biosensor and method for measuring concentration of phenytoin
AssigneeNational Taiwan University
InventorsLong-Sun Huang, Lung-Yi Lin, Yu-Chen Chang, Yotsapoom Pheanpanitporn
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Abstract
The present disclosure relates to a phenytoin biosensor. In some embodiments, the phenytoin biosensor may comprise a microcantilever, a self-assembly monolayer, and a phenytoin antibody layer. The self-assembly monolayer may immobilize on the microcantilever surface. The phenytoin antibody layer may immobilize on the self-assembly monolayer. The phenytoin antibody layer may be used to bind with phenytoin drug samples. The present disclosure further relates to methods for measuring the concentration of phenytoin drug samples.
Claims16
A phenytoin biosensor comprising:
- a microcantilever;
- a self-assembly monolayer immobilized on the microcantilever;
- and
- a phenytoin antibody layer immobilized on the self-assembly monolayer, the phenytoin antibody layer operable to bind with phenytoin drug samples.
A method for measuring a concentration of phenytoin, comprising:
- manufacturing a microcantilever with a piezoresistive layer;
- binding a plurality of self-assembly molecules to the microcantilever;
- activating the bonded self-assembly molecules;
- binding a plurality of phenytoin antibodies with the activated self-assembly molecules;
- binding a plurality of phenytoin drug samples with the phenytoin antibodies;
- measuring a change of resistance of the piezoresistive layer;
- and
- calculating the concentration of the phenytoin according to a pre-determined relationship between the measured resistance change and the concentration of the phenytoin drug samples.
A method for measuring a concentration of phenytoin, comprising:
- manufacturing a microcantilever with a field effect transistor;
- binding a plurality of self-assembly molecules to the microcantilever;
- activating the bonded self-assembly molecules;
- binding a plurality of phenytoin antibodies with the activated self-assembly molecules;
- binding a plurality of phenytoin drug samples with the phenytoin antibodies;
- measuring a change of current of the field effect transistor;
- and
- calculating the concentration of phenytoin according to a pre-determined relationship between the measured current change and the concentration of the phenytoin drug samples.
Dependencies are inferred from the claim text.