Nucleic Acids, Polypetides, and Methods for Modulating Apoptosis
AssigneeSenesco Technologies, Inc.
InventorsCatherine Taylor, Tzann-Wei Wang, Larry Petrov, John C. Carlson, Richard Narayansingh, John E. Thompson
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Abstract
The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific and DHS useful in such methods.
Claims13
1-63. (canceled)
A method of inhibiting apoptosis in a cell comprising administering to the cell an oligonucleotide that is antisense to the 3′-UTR of a mammalian nucleic acid molecule encoding apoptosis-specific eIF-5A, wherein the antisense oligonucleotide inhibits apoptosis-specific eIF-5A expression.
An apoptosis inhibiting agent comprising an antisense oligonucleotide against the 3′-UTR of a mammalian nucleic acid molecule encoding apoptosis-specific eIF-5A, wherein the antisense oligonucleotide inhibits apoptosis-specific eIF-5A expression.
A method of inhibiting apoptosis in a cell comprising administering to the cell an agent that inhibits the activity of deoxyhypusine synthase (DHS).
Dependencies are inferred from the claim text.