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AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Serv
InventorsChandan Das, Ashley A. Jaeger, Thomas J. Pohida, Michael M. Gottesman, Randall H. Pursley, Philip G. McQueen, Nicole Y. Morgan
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The present disclosure is directed to embodiments of microstructured membranes, methods of fabricating microstructured membranes, bioreactors housing microstructured membranes, and methods of using bioreactors and microstructured membranes. In some embodiments, the present disclosure allows culturing of cellular tissues in an environment which more accurately resembles a native environment. In some more specific embodiments, the present disclosure allows culturing of tumor cells on a membrane having a microfabricated pattern which mimics a native vasculature system.
A microfabricated oxygen permeable membrane comprising a base surface with pillars that project away from the surface, the pillars having a height of greater than about 1 μm and less than about 1 mm to form blood vessel mimetics.
A cell culture bioreactor comprising:
A method of culturing cells in a bioreactor, comprising:
A method of fabricating a microfabricated membrane, comprising:
Dependencies are inferred from the claim text.