Modular platform for multi-tissue integrated cell culture

A method for culturing a plurality of cells, the method comprising:

• providing at least one open, cell culture vessel, reversibly coupled to a control plate, the control plate comprising a constant volume pump with a central displacement chamber having a displacement pump and at least four channels radiating out from the central displacement chamber, wherein each of the at least four channels are coupled in line with a membrane valve;
• activating a first membrane valve coupled to a first channel of the at least four channels to close the first channel;
• drawing, with the displacement pump, a first fluid into the displacement chamber;
• activating a second membrane valve coupled to a second channel of the at least four channels to close the second channel;
• deactivating the first membrane valve to open the first channel;
• evacuating, with the displacement pump, the fluid from the displacement chamber;
• and
• flowing the first fluid through the first channel.