Device For Isolating A Fraction In A Biological Sample

The device of claim I further comprising:

• a reagent zone downstream of and in communication with the isolation zone, the reagent zone receiving a reagent therein;
• a replacement zone in fluid communication with the reagent zone;
• and
• a microporous membrane separating the reagent zone and the replacement zone.

A device for isolating a fraction in a biological sample, the fraction being bound to solid phase substrate to define a fraction-bound solid phase substrate, the device comprising:

• an input zone for receiving the biological sample therein, the input zone partially defined by a lower surface lying in a first plane;
• a second zone for receiving a fluid therein, the second zone partially defined by a lower surface;
• a passage extending along an axis and having an input communicating with the input zone and an output communicating with the second zone;
• and
• a force capturing the fraction-bound solid phase substrate, the force being at a selected angle to gravity and being movable between a first position adjacent the input zone and a second position adjacent the second zone;
• wherein:
• the biological sample and the fluid having an interface with a surface tension, the surface tension of the interface retaining the biological sample in the passage and the fluid in the second zone;
• and
• the captured fraction-bound solid phase substrate moves from the input zone to the second zone in response to the force moving from the first position to the second position.