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AssigneeIndustry-Academic Cooperation Foundation, Yonsei University
InventorsDoo Sik Kim, Hee Doo Lee, Yeon Hyang Kim, Bon Hun Koo, Ok Hee Jeon
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The present invention relates to a method for preparing microvesicular ADAM15, comprising: (a) a step of activating protein kinase C (PKC) of separated mammalian cells; and (b) a step of separating microvesicle-containing ADAM15 from the mammalian cells. According to the present invention, a method for preparing microvesicular ADAM15 from mammalian cells is provided, and a novel cell regulation mechanism mediated by ADAM proteins is provided by the study of the function of the microvesicular ADAM15. Further, the present invention may provide a novel anti-cancer drug using microvesicular ADAM15, which inhibits adhesion, proliferation and migration of tumor cells.
A method for preparing microvesicular ADAM15 from mammalian cells, the method comprising:
A method for inducing microvesicular ADAM15 generation, the method comprising a PKC activator.
A method for preparing microvesicular ADAM15, the method comprising:
A Method for inducing microvesicular ADAM15 generation from macrophages, the method comprising an immune adjuvant.
Dependencies are inferred from the claim text.