Il-1 binding proteins

An isolated nucleic acid encoding an amino acid sequence of an IL-1β binding protein comprising an antigen binding domain, said binding protein capable of binding human IL-1β, said antigen binding domain comprising six CDRs:

• CDR-H1CDR-H2CDR-H3CDR-L1 CDR-L2 and CDR-L3 as defined below:
• (SEQ ID NO:
• 190)
• CDR-H1:
• X1-Y-D-M-S,
• wherein;
• X1 is S, K or R;
• (SEQ ID NO:
• 191)
• CDR-H2:
• Y-X2-S-X4-G-G-X7-G-T-Y-Y-P-D-X14-X15-K-G,
• wherein;
• X2 is I or V;
• X4 is S or H;
• X7 is G or A;
• X14 is T or S;
• and
• X15 is V or A;
• (SEQ ID NO:
• 192)
• CDR-H3:
• G-G-V-X4-K-G-X7-F-D-X10,
• wherein;
• X4 is T or Y;
• X7 is Y or C;
• and
• X10 is V, E, L, M, Q, or Y;
• (SEQ ID NO:
• 193)
• CDR-L1:
• R AS G N I X7 X8 X9 L X11,
• wherein;
• X7 is H, Y, or W;
• X8 is N, G, T, Q, E, H, D, or K;
• X9 is Y or W;
• and
• X11 is T, A, or N;
• (SEQ ID NO:
• 194)
• CDR-L2:
• X1-A-K-X4-L-X6-X7,
• wherein;
• X1 is N, Q, or D;
• X4 is T, N, I, E, or S;
• X6 is A, M, or E;
• and
• X7 is D, E, S, or A;
• and
• (SEQ ID NO:
• 195)
• CDR-L3:
• Q-X2-F-W-X5-X6-P-X8-X9,
• wherein;
• X2 is H or Q;
• X5 is S, N, T, K, R, or M;
• X6 is I or L;
• X8 is Y or A;
• and
• X9 is T, I,
• and
• N;
• (SEQ ID NO:
• 17)
• except that when CDR-H1 is S-Y-D-M-S,
• then:
• (SEQ ID NO:
• 18)
• CDR-H2 cannot be Y-I-S-S-G-G-G-G-T-Y-Y-P-D-T-V-K-G;
• (SEQ ID NO:
• 19)
• CDR-H3 cannot be G-G-V-T-K-G-Y-F-D-V;
• (SEQ ID NO:
• 20)
• CDR-L1 cannot be R-A-S-G-N-I-H-N-Y-L-T;
• (SEQ ID NO:
• 21)
• CDR-L2 cannot be N-A-K-T-L-A-D;
• and
• (SEQ ID NO:
• 22)
• CDR-L3 cannot be Q-H-F-W-S-I-P-Y-T.