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US 2014/0212908 A1Published application
Fetal Pulmonary Cells and Uses Thereof
AssigneeDrexel University
InventorsPeter I. Lelkes, Mark J. Mondrinos, Christine M. Finck
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Abstract
Isolated mixed populations of fetal pulmonary cells, engineered three-dimensional tissue constructs of these cells, and uses thereof in identifying therapeutic agents which augment, repair, and/or replace dysfunctional native lung and to perform in vitro studies such as pharmaceutical screening, models for lung development and disease and characterization of chemical or mechanical injury are provided.
Claims15
-8. (canceled)
A method for assessing pharmaceutical activity and/or toxicity of an agent in pulmonary tissue comprising:
- contacting an engineered three-dimensional pulmonary tissue construct with the agent, wherein the engineered construct comprises:
- a population of fetal pulmonary cells comprising epithelial, endothelial, and mesenchymal cells;
- a three-dimensional matrix of natural polymers comprising collagen or elastin;
- and
- a combination of fibroblast growth factors (FGF);
- and
- assessing an effect of the agent on the engineered three-dimensional pulmonary tissue construct.
4 more elements
(canceled)
Dependencies are inferred from the claim text.