Nmr methods for monitoring blood clot formation
AssigneeT2 Biosystems, Inc.
InventorsThomas J. Lowery, JR., Vyacheslav Papkov, Walter W. Massefski, JR., Rahul K. Dhanda, Edward C. Thayer
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Abstract
The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.
Claims39
A method of monitoring a clotting or dissolution process in a first blood sample comprising:
- (i) making a series of magnetic resonance relaxation rate measurements of water in said first blood sample;
- (ii) transforming said measurements using an algorithm that distinguishes two or more separate water populations within said first blood sample, wherein each separate water population is characterized by one or more magnetic resonance parameters having one or more values;
- and
- (iii) on the basis of the results of step (ii), monitoring said process.
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Dependencies are inferred from the claim text.