Screening method for therapeutic agent for chondropathy and modified chondrocyte for treatment of chondropathy
AssigneeKyoto University
InventorsNoriyuki Tsumaki, Hiroshi Takemori
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Abstract
The use of salt-inducible kinase 3 allows screening for a substance having an effect of increasing cartilage volume and/or an effect of normalizing chondrocyte differentiation. A modified chondrocyte in which the expression or function of salt-inducible kinase 3 gene is inhibited or enhanced can be used to ameliorate a disease associated with reduced cartilage volume and/or a disease associated with impaired cartilage growth.
Claims8
A screening method for a substance having an effect of increasing cartilage volume and/or an effect of normalizing chondrocyte differentiation, the method comprising using salt-inducible kinase 3 (SIK3).
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Dependencies are inferred from the claim text.