Identity Elucidation of Unknown Metabolites
AssigneesMetabolon, Inc., Helmholtz Zentrum Munchen
InventorsMichael Milburn, Gabriele Kastenmueller, Jan Krumsiek, Karsten Suhre
Life of this patent
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Abstract
A method of elucidating the identity of an unknown metabolite comprising measuring amounts of known and unknown metabolites in subjects; associating the unknown metabolite with a specific gene from a gene association study; determining a protein associated with the specific gene and analyzing information for the protein; associating the unknown metabolite with concentrations and/or ratios of other metabolites in subjects; obtaining chemical structural data for the unknown metabolite; and using the information obtained to elucidate the identity of the unknown metabolite.
Claims21
A method of elucidating the identity of an unknown metabolite, comprising:
- (a) measuring amounts of known and unknown metabolites in subjects;
- (b) associating an unknown metabolite with a specific gene from a gene association study;
- (c) determining a protein associated with the specific gene and analyzing information for the protein;
- (d) associating the unknown metabolite with concentrations and/or ratios of other metabolites in the subjects using a partial correlation network;
- (e) obtaining chemical structural data for the unknown metabolite;
- and
- (f) deriving from the information obtained from steps (a) through (e) the identity of the unknown metabolite.
A method of elucidating the identity of an unknown metabolite, comprising:
- (a) measuring amounts of known and unknown metabolites in subjects;
- (b) associating an unknown metabolite with a specific gene from a gene association study;
- (c) determining a protein associated with the specific gene and analyzing information for the protein;
- (d) reviewing the identity and/or characteristics of the other metabolites associated with the specific gene from the gene association study;
- and/or identifying the biochemical pathway with which at least a portion of the other metabolites associated with the specific gene are involved;
- (e) obtaining chemical structural data for the unknown metabolite;
- and
- (f) deriving from the information obtained from steps (a) through (e) the identity of the unknown metabolite.
A method of elucidating the identity of an unknown metabolite, comprising:
- (a) measuring amounts of known and unknown metabolites in subjects;
- (b) associating an unknown metabolite with concentrations and/or ratios of other metabolites in the subjects using a partial correlation network;
- (c) reviewing the identity and/or characteristics of the other metabolites associated with the unknown metabolite;
- and/or identifying the biochemical pathway with which at least a portion of the other metabolites associated with the unknown metabolite are involved;
- (d) obtaining chemical structural data for the unknown metabolite;
- and
- (e) deriving from the information obtained from steps (a) through (d) the identity of the unknown metabolite.
Dependencies are inferred from the claim text.