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US 2014/0212505 A1Published application
Spatial arrangement of particles in a drinking device for oral delivery of pharmaceuticals
AssigneeParticle Dynamics International, LLC
InventorsJonathan David Bortz, Yury Lagoviyer, Paul Timothy Brady
Life of this patent
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Abstract
The present invention relates to spatially arranging a plurality of particles in a device for the oral delivery of a pharmaceutical. In particular, the plurality of particles is utilized for the oral delivery of a pharmaceutical to a subject via the drinking device.
Claims21
1-65. (canceled)
A method of delivering a pharmaceutically active agent to a subject, the method comprising:
- a subject imbibing an aqueous fluid using a drinking device, wherein the drinking device comprises a hollow tube having two ends, a plurality of particles comprising a pharmaceutically active agent, and a plurality of particle containment elements that restrain the particles within the hollow tube while the subject imbibes the aqueous fluid, wherein the particles are spatially arranged within the device to achieve a specific flow resistance not greater than about 50 Torr/mm such that a dosage comprising an effective amount of the pharmaceutically active agent is orally delivered to the subject as fluid flows over the particles during said imbibing.
A method of delivering a pharmaceutically active agent to a subject, the method comprising:
- a subject imbibing an aqueous fluid using a drinking device, wherein the drinking device comprises a hollow tube having two ends, a plurality of particles comprising a pharmaceutically active agent and an indicator coating, and a plurality of particle containment elements that restrain the particles within the hollow tube while the subject imbibes the aqueous fluid and a dosage comprising an effective amount of the pharmaceutically active agent is orally delivered to the subject as fluid flows over the plurality of particles during said imbibing.
A method of delivering a pharmaceutically active agent to a subject, the method comprising:
- a subject imbibing an aqueous fluid using a drinking device, the drinking device comprising a hollow tube having two ends, a plurality of particles comprising a pharmaceutically active agent, and a plurality of particle containment elements that restrain the particles within the hollow tube while the subject imbibes the aqueous fluid and a dosage comprising an effective amount of the pharmaceutically active agent is orally delivered to the subject as fluid flows over the plurality of particles during said imbibing, the particles having a tensile strength of not less than about 0.01 MPa and a friability of not more than about 15%.
Dependencies are inferred from the claim text.