Compositions containing diverse natural antigens and uses thereof in balancing immune responses
AssigneeAcademia Sinica
InventorTse Wen Chang
Life of this patent
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Abstract
Compositions containing sterilized antigens with a high diversity, which can be collected from primitive jungle areas, and uses thereof for balancing immune responses and treating immunological diseases in a subject.
Claims90
A composition comprising a mixture of sterilized antigens, wherein the mixture of sterilized antigens is prepared by a process comprising:
- placing a particle collector in a jungle area,
- harvesting airborne antigens collected in the particle collector, and
- sterilizing harvested airborne antigens to obtain the mixture of the sterilized antigens.
A kit comprising multiple preparations of sterilized antigen mixtures, each of the preparations being prepared by a process comprising:
- placing a particle collector in a jungle area,
- harvesting airborne antigens collected in the particle collector, and
- sterilizing harvested airborne antigens to obtain a preparation of sterilized antigen mixture;
- wherein the multiple preparations of sterilized antigen mixtures are obtained from geographically different jungle areas or from the same jungle area but during different time periods.
A kit comprising multiple preparations of sterilized antigen mixtures, each of the preparations containing at least five sterilized natural antigens, wherein:
- (a) the amount of each antigen in each preparation is effective in inducing IgE antibody production, and
- (b) at least 20% of the natural antigens in one preparation are not present in any other preparations in the kit.
A method for preparing a composition, comprising:
- placing a particle collector in a jungle area,
- harvesting airborne antigens collected in the particle collector, and
- sterilizing the airborne antigens to obtain a composition, which comprises a mixture of sterilized antigens.
A method for enhancing IgE production in a subject, comprising administering to a subject in need thereof at least four multiple preparations of sterilized antigen mixtures sequentially, wherein
- (a) each of the preparations contains at least five sterilized natural antigens,
- (b) the amount of each antigen in each preparation is effective in inducing IgE antibody production,
- (c) at least 20% of the natural antigens in one preparation are not present in any other preparations in the kit, and
- (d) the natural antigens in the multiple preparations are obtained from a place in which the subject has not lived for longer than 2 years.
Dependencies are inferred from the claim text.