New abuse-resistant pharmaceutical composition for the treatment of opioid dependence
AssigneeOrexo AB
InventorAndreas Fischer
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Abstract
There is provided pharmaceutical compositions for the treatment of e.g. opioid dependency comprising microparticles of a pharmacologically-effective amount of buprenorphine, or a pharmaceutically-acceptable salt thereof, in associative admixture with particles comprising a weak acid, or particles comprising weakly-acidic buffer forming materials. The composition may further comprise a disintegrant and/or particles of a pharmacologically-effective amount of naloxone, or a pharmaceutically-acceptable salt thereof. The compositions are useful in the treatment of opioid dependency/addiction and/or pain.
Claims14
1-23. (canceled)
A tablet suitable for sublingual administration comprising:
- microparticles of a pharmacologically-effective amount of buprenorphine, or a pharmaceutically-acceptable salt thereof, in intimate contact with particles comprising citric acid;
- a pharmacologically-effective amount of naloxone, or a pharmaceutically-acceptable salt thereof;
- and
- a disintegrant selected from the group croscarmellose sodium, sodium starch glycolate, crosslinked polyvinylpyrrolidone and mixtures thereof.
Dependencies are inferred from the claim text.