Nanoparticulate compositions of tubulin inhibitor compounds

A nanoparticulate pharmaceutical composition comprising particles with an effective average size of from about 15 nm to about 50 microns of at least one tubulin inhibitor compound of

• wherein:
• X is hydrogen, halogen, alkyl, cycloalkyl, heterocycloalkyl, alkenyl, cycloalkenyl, heterocycloalkenyl, acyl, carboxy, alkoxy, hydroxy, functionally modified hydroxy group, aryl, heteroaryl,
• wherein Y and Z are, independently, NR, O, or S, wherein R is hydrogen, alkyl, aryl, acyl, cycloalkenyl, heterocycloalkenyl, alkenyl, cycloalkenyl, heterocycloalkenyl, aminocarbonyl,
• R3 and R3′ are, independently, alkyl, aryl, heteroaryl,
• or X is NR8R9, wherein, R8 and R9 are, independently, hydrogen, alkyl, cycloalkyl, heterocycloalkyl, alkenyl, cycloalkenyl, heterocycloalkenyl, acyl, aryl, or heteroaryl;
• A, B, C and D are, independently, nitrogen or carbon,
• provided if A is nitrogen, R4 is absent, and if A is carbon, R4 is either hydrogen, halogen, or alkyl,
• if B is nitrogen, R5 is absent, and if B is carbon, R5 is hydrogen, halogen, or alkyl,
• if C is nitrogen, R6 is absent, and if C is carbon, R6 is hydrogen, halogen, or alkyl,
• if D is nitrogen, R7 is absent, and if D is carbon, then R7 is hydrogen, halogen, or alkyl;
• R1 is hydrogen, alkyl, alkylaryl, acyl, or aryl;
• R2 is hydrogen, alkyl, acyl, aryl, alkoxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, cycloalkoxycarbonyl, heterocycloalkoxycarbonyl, alkenyloxycarbonyl, cycloalkenyloxycarbonyl and heterocycloalkenyloxycarbonyl;