Tablet for pulsed delivery
AssigneeShionogi & Co., Ltd.
InventorsBruce Cao, Sandra E. Wassink, Donald J. Treacy, JR., Beth A. Burnside, Colin E. Rowlings, John A. Bonck
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Abstract
A pharmaceutical tablet comprising an immediate release portion containing an active ingredient and a delayed release portion, wherein the delayed release portion comprises an enteric-coated layer and within the enteric-coated layer there is at least one member selected from the group consisting of enteric-coated microparticle dosage forms containing an active ingredient and enteric-coated mini-tablet dosage forms containing an active ingredient, is disclosed.
Claims21
A pharmaceutical tablet, said tablet comprising an immediate release portion containing an active ingredient and a delayed release portion, wherein said delayed release portion comprises an enteric-coated layer and within said enteric-coated layer there is at least one member selected from the group consisting of enteric-coated microparticle dosage forms containing an active ingredient and enteric-coated minitablet dosage forms containing an active ingredient.
A method for preparing a pharmaceutical tablet having an immediate release portion and a delayed release portion for immediate and delayed release delivery of at least one active ingredient, said method comprising the steps of:
- (a) formulating a delayed release portion that comprises a core tablet and an enteric coating, such that said core tablet comprises at least one member selected from the group consisting of enteric-coated microparticle dosage forms containing an active ingredient and enteric-coated mini-tablet dosage forms containing an active ingredient;
- and such that said enteric coating covers said core tablet;
- and (b) applying an immediate release portion containing an active ingredient as an immediate release layer over said delayed release portion such that said immediate release layer at least partially covers said delayed release portion.
-22. (canceled)
Dependencies are inferred from the claim text.