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US 2014/0212472 A1Published application
Methods of Treatment Using A Pentapeptide Derived From The C-Terminus Of Glucagon-Like Peptide 1 (GLP-1)
AssigneeThe General Hospital Corporation
InventorsJoel F. Habener, Eva Tomas-Falco
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Abstract
Methods of treating obesity, metabolic syndrome, hepatic and non-hepatic steatosis, and diabetes using a pentapeptide, LVKGRamide, derived from the C-terminus of Glucagon-Like Peptide 1 (GLP-1).
Claims18
A therapeutic composition comprising an isolated peptide consisting essentially of a sequence:
- (SEQ ID NO:
- 3)
- Leu-Val-(Lys/Arg)-Gly-Arg-Xaa,
- wherein Xaa can be Gly, Gly-Arg, Gly-Arg-Gly, or absent,
- and a physiologically acceptable carrier.
2 more elements
A fusion peptide comprising a first portion consisting essentially of a sequence:
- Leu-Val-(Lys/Arg)-Gly-Arg-Xaa (SEQ ID NO:3), wherein Xaa can be Gly, Gly-Arg, Gly-Arg-Gly, or absent,
- fused to a cell-penetrating peptide.
Dependencies are inferred from the claim text.