Surface functional bioactive glass scaffold for bone regeneration
AssigneeMissouri University of Science and Technology
InventorsMohamed N. Rahaman, Xin Liu, B. Sonny Bal, Yongxing Liu
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Abstract
A bioactive glass scaffold treated to modify the surface of the bioactive glass scaffold for regenerating new bone tissue is disclosed. In some embodiments, the bioactive glass scaffold may include pores in a grid-like structure to promote the ingrowth of bone tissue, and the modified surface layer may include a hydroxyapatite-like surface. The bioactive glass scaffold is inexpensive and easy to fabricate and regenerates new bone faster than the existing synthetic implants. The bioactive glass scaffold may be loaded with a biomolecule, such as BMP-2, for delivery to the implantation site.
Claims20
A bioactive glass scaffold for new bone formation, the bioactive glass scaffold comprising:
- a bioactive glass in a three-dimensional macroporous grid-like microstructure;
- and
- a modified surface layer on the surface of the bioactive glass,
- wherein the modified surface layer increases the surface area of the bioactive glass, and
- wherein at least part of the modified surface layer comprises calcium phosphate.
A method of manufacturing a bioactive glass scaffold comprising:
- grinding a bioactive glass into fine particles;
- mixing the fine particles of bioactive glass with a processing aid and a liquid to form a slurry;
- fabricating a three-dimensional macroporous grid-like microstructure of the slurry to form a bioactive glass scaffold;
- and
- modifying the surface of the three-dimensional macroporous grid-like structure of the bioactive glass scaffold with a glass modifier,
- wherein the modified surface layer increases the surface area of the bioactive glass scaffold to enhance new bone formation, and
- wherein at least part of the modified surface layer comprises calcium phosphate.
Dependencies are inferred from the claim text.