Prevention of salmonella recrudescense
AssigneeUniversiteit Gent
InventorsFrank Pasmans, Elin Verbrugghe, Freddy Haesebrouck, Filip Eddy Boyen
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Abstract
The present invention relates to novel Salmonella mutants, to a process for producing the same and to vaccines containing the same, wherein said Salmonella mutants are characterized in that they are not responsive to stress-related recrudescence. It is accordingly an object of the present invention to provide the use of said Salmonella mutants in the vaccination of animals, in particular mammals and birds, more in particular pigs, poultry and cattle.
Claims22
1-13. (canceled)
A Salmonella mutant strain having at least one genetic modification within the cbpA gene or the scs locus.
A method for converting a Salmonella vaccine strain into a Salmonella mutant vaccine strain by introducing at least one genetic modification within the cbpA gene or the scs locus into said strain;
- said method comprising:
- obtaining a Salmonella strain;
- genetically modifying the cbpA gene or the scs locus of said vaccine strain;
- thereby obtaining said Salmonella mutant vaccine strain.
Dependencies are inferred from the claim text.