Lyme Disease Vaccine
AssigneeVirginia Commonwealth University
InventorsChristopher G. Earnhart, Richard T. Marconi
Life of this patent
Estimating the term…
Abstract
Antigenic polypeptides comprising linear immunodominant epitopes of Borrelia outer surface protein A (OspA) or Borrelia outer surface protein C (OspC) are useful as vaccines against Lyme disease, and as diagnostics for detecting Borrelia infections. The OspA and OspC antigenic polypeptides typically comprise a plurality of peptides representing epitope containing regions from multiple distinct phyletic groups. The antigenic polypeptides may also include epitopes from both Borrelia OspA and Borrelia OspC.
Claims9
1-19. (canceled)
A recombinant or synthetic fusion protein comprising
- at least one linear epitope from Borrelia outer surface protein A (OspA), said at least one linear epitope having an amino acid sequence STLTITVNSKKTKDLVFTKE (SEQ ID NO:
- 1).
A method for ascertaining whether an individual has been exposed to or infected with Borrelia, or both, comprising the steps of
- obtaining a biological sample from said individual,
- exposing said biological sample to a recombinant or synthetic fusion protein comprising at least one linear epitope from Borrelia outer surface protein A (OspA), said at least one linear epitope having an amino acid sequence STLTITVNSKKTKDLVFTKE (SEQ ID NO:
- 1).
An isolated recombinant or synthetic fusion protein comprising
- a plurality of linear epitopes from Borrelia outer surface protein A (OspA), said plurality of linear epitopes having amino acid sequences
- (SEQ ID NO:
- 1)
- STLTITVNSKKTKDLVFTKE,
- (SEQ ID NO:
- 3)
- STLTISKNRTKTKQLVFTKE,
- (SEQ ID NO:
- 9)
- NTLTVSADSKKIKDFVFLTD,
- and
- (SEQ ID NO:
- 15)
- KTLTVSADSKKIKDFVFLTD.
Dependencies are inferred from the claim text.