Humanized Anti-Factor D Antibodies And Uses Thereof
AssigneeGenentech, Inc.
InventorsARTHUR HUANG, ROBERT KELLEY, HENRY LOWMAN, MENNO VAN LOOKEREN CAMPAGNE, CHARLES WINTER
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Abstract
The invention relates to anti-Factor D antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
Claims18
1-76. (canceled)
An anti-Factor D antibody or an antigen-binding fragment thereof, wherein the anti-Factor D antibody or antigen-binding fragment thereof comprises:
- (a) a heavy chain variable domain comprising:
- i. an HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 39;
- ii. an HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 40;
- and iii. an HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 41;
- and
- (b) a light chain variable domain comprising:
- i. an HVR-L1 comprising the amino acid sequence of SEQ ID NO:
- 30;
- ii. an HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 35;
- and iii. an HVR-L3 comprising the amino acid sequence of SEQ ID NO:
- 38;
- wherein the amino acid residue at position 1 of the heavy chain variable domain is an E.
An anti-Factor D antibody or an antigen-binding fragment thereof, wherein the anti-Factor D antibody or antigen-binding fragment thereof comprises the heavy chain variable domain sequence of SEQ ID NO:
- 19 and the light chain variable domain sequence of SEQ ID NO:
- 7.
The anti-Factor D antibody or antigen-binding fragment of claim 1 or 2, wherein the anti-Factor D antibody is a humanized antibody.
The anti-Factor D antibody or antigen-binding fragment of claim 1 or 2, wherein the Factor D is mammalian Factor D.
The anti-Factor D antibody or antigen-binding fragment of claim 1 or 2, wherein the Factor D is human Factor D.
The anti-Factor D antibody or antigen-binding fragment of claim 1 or 2, wherein the anti-Factor D antibody is a monoclonal antibody.
The anti-Factor D antibody or antigen-binding fragment of claim 1 or 2, wherein the antigen-binding fragment is a Fab, Fab′-SH, Fv, scFv, or (Fab′)2 fragment.
The anti-Factor D antibody or antigen-binding fragment of claim 1 or 2, which is produced in bacteria.
The anti-Factor D antibody or antigen-binding fragment of claim 1 or 2, which is produced in CHO cells.
A pharmaceutical formulation comprising the anti-Factor D antibody or antigen-binding fragment of claim 1 or 2, and a pharmaceutically acceptable diluent, carrier or excipient.
A kit comprising the anti-Factor D antibody or antigen-binding fragment of claim 1 or 2, and instructions for administering said antibody to treat a complement-associated disorder.
Dependencies are inferred from the claim text.