Toll-Like Receptor 3 Antagonists
AssigneeJanssen Biotech, Inc.
InventorsMark Cunningham, Yiqing Feng, Katharine Heeringa, Jinquan Luo, Robert Rauchenberger, Mark Rutz, Lani San Mateo, Robert Sarisky, Vedrana Stojanovic-Susulic, Raymond Sweet, Fang Teng, Alexey Teplyakov, Sheng-Jiun Wu
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Abstract
Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
Claims26
1) An isolated antibody or fragment thereof that binds toll-like receptor 3 (TLR3), wherein the antibody binds at least one TLR3 amino acid residue selected from the group consisting of residues D116 and K145 of SEQ ID NO:
- 2.
5) An isolated antibody or fragment thereof that binds toll-like receptor 3 (TLR3), wherein the antibody competes for TLR3 binding with a monoclonal antibody comprising:
- a) the heavy chain variable region of SEQ ID NO:
- 214 and the light chain variable region of SEQ ID NO:
- 211;
- or
- b) the heavy chain CDR 1, 2 and 3 amino acid sequences as shown in SEQ ID NOs:
- 70, 77 and 72 and the light chain CDR 1, 2 and 3 amino acid sequences as shown in SEQ ID NOs:
- 67, 68 and 78.
25) An isolated antibody heavy chain variable region comprising the amino acid sequence shown in SEQ ID NOs:
- 8, 10, 18, 20, 22, 24, 26, 28, 30, 32, 34, 212, 213 or 214.
26) An isolated antibody light chain variable region comprising the amino acid sequence shown in SEQ ID NOs:
- 5, 7, 17, 19, 21, 23, 25, 27, 29, 31, 33, 209, 210 or 211.
Dependencies are inferred from the claim text.