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AssigneeImmunomedics, Inc.
InventorsChien-Hsing Chang, David M. Goldenberg, Hans J. Hansen, Edmund A. Rossi
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Disclosed are methods and compositions of anti-B cell antibodies, preferably anti-CD22 antibodies, for diagnosis, prognosis and therapy of B-cell associated diseases, such as B-cell malignancies, autoimmune disease and immune dysfunction disease. Preferably, the antibodies induce trogocytosis of B-cell antigens, such as CD19, CD20, CD21, CD22, CD79b, CD44, CD62L, or β7-integrin. Trogocytosis may play a significant role in determining antibody efficacy, disease responsiveness and prognosis of therapeutic intervention and trogocytosis-dependent responses may be monitored by measuring the levels of trogocytosis of one or more B-cell surface antigens induced by the bispecific antibody.
A method of treating a B-cell associated disease, selected from the group consisting of B-cell malignancy, autoimmune disease and immune dysfunction disease, comprising administering to a subject with the disease an antibody that binds to B cells, wherein the antibody induces trogocytosis of one or more B-cell surface antigens.
A complex comprising:
Dependencies are inferred from the claim text.